منابع مشابه
ONTARGET still OFF-TARGET?
Several large randomized, controlled trials have demonstrated that interruption of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibition (ACEi) or angiotensin receptor blockade (ARB) delays the progression of renal and cardiovascular disease.1–6 These beneficial effects of ACEis and ARBs are likely to be mediated through reductions in blood pressure and albuminu...
متن کاملONTARGET still OFF - TARGET ?
Several large randomized, controlled trials have demonstrated that interruption of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibition (ACEi) or angiotensin receptor blockade (ARB) delays the progression of renal and cardiovascular disease.1–6 These beneficial effects of ACEis and ARBs are likely to be mediated through reductions in blood pressure and albuminu...
متن کاملSeedSeq: Off-Target Transcriptome Database
Detection of potential cross-reaction between a short oligonucleotide sequence and a longer (unintended) sequence is crucial for many biological applications, such as high content screening (HCS), microarray nucleotide probes, or short interfering RNAs (siRNAs). However, owing to a tolerance for mismatches and gaps in base-pairing with target transcripts, siRNAs could have up to hundreds of pot...
متن کاملOff-target cannabinoid effects mediated by GPR55.
Given the vast therapeutic potential of the endocannabinoid system, the revelation of a novel cannabinoid-sensitive target was treated with great excitement. The orphan G-protein coupled receptor 55 (GPR55) was initially touted as a novel cannabinoid target in early industrial patent literature. Consequently, numerous studies have revealed GPR55 expression in a diverse array of cells and tissue...
متن کاملOff-Label Promotion, On-Target Sales
For prescription drugs, demonstrated benefits define the parameters of acceptable risks. For example, liver toxicity may be acceptable in a drug approved for cancer, but unacceptable in a drug approved for acne. Government regulatory bodies review laboratory, animal, and human data to confirm that a drug has the claimed efficacy and safety prior to approving its release in the market for specif...
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ژورنال
عنوان ژورنال: Nature
سال: 1989
ISSN: 0028-0836,1476-4687
DOI: 10.1038/340110b0